Principal Clinical Scientist
About this role
About the Role What if your career-long expertise in clinical trial design and regulatory science could directly shape how AI understands and evaluates clinical evidence? We're looking for a Principal Clinical Scientist to bring senior-level rigor to AI-driven research workflows. You'll work with cutting-edge AI systems being developed by leading research labs — ensuring the clinical intelligence built into these models meets the standards expected in real-world regulatory environments. This is a fully remote, flexible contract role. No AI background needed — just deep command of clinical research and regulatory science. - Organization: Alignerr - Type: Hourly Contract - Location: Remote - Commitment: 10–40 hours/week What You'll Do - Design and review clinical trial protocols used to generate high-quality, regulator-ready datasets for AI training - Interpret and audit clinical trial results to ensure accuracy, consistency, and regulatory relevance - Evaluate AI-generated clinical analyses for scientific soundness and alignment with regulatory expectations (FDA, EMA, or equivalent) - Provide expert, structured feedback that improves how AI models reason about clinical trial data, endpoints, and outcomes - Help define quality standards for clinical data used across frontier AI research projects Who You Are - Senior-level experience designing clinical trial protocols for regulatory submission - Deep expertise interpreting clinical data for agencies such as the FDA, EMA, or equivalent bodies - Strong background in clinical research methodology, biostatistics, translational science, or a closely related field - Naturally rigorous and detail-oriented — you hold data and analysis to a high standard - Able to communicate expert clinical judgment clearly in written feedback - Comfortable working independently in a self-directed, asynchronous environment Nice to Have - Prior experience with data annotation, data quality evaluation, or AI model evaluation workflows - Background in pharmacology, clinical pharmacokinetics, or outcomes research - Experience working across multiple therapeutic areas or regulatory jurisdictions - Familiarity with AI tools or structured evaluation platforms Why Join Us - Work directly on frontier AI systems making a real impact on clinical and biomedical research - Fully remote and flexible — work when and where it suits you - Freelance autonomy with the structure of meaningful, expert-level work - Influence how AI understands and evaluates real-world clinical evidence at a foundational level - Potential for ongoing work and contract extension as new projects launch - Global collaboration with world-class AI researchers and scientists
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