Principal Clinical Scientist
About this role
About the Role What if your career-long expertise in clinical trial design and regulatory science could directly shape how AI reasons about medical evidence for millions of patients worldwide? We're looking for a Principal Clinical Scientist to bring senior-level rigor to cutting-edge AI research workflows. In this role, your deep knowledge of regulatory-grade clinical data will help ensure that the AI systems influencing biomedical research are built on a foundation of scientific integrity — the kind that holds up to real-world scrutiny. This is a fully remote, flexible contract role designed for experienced clinical scientists who want meaningful, high-impact work on their own schedule. - Organization: Alignerr - Type: Hourly Contract - Location: Remote - Commitment: 10–40 hours/week What You'll Do - Design and critically review clinical trial protocols used to generate high-quality, regulator-ready datasets for AI training - Interpret and audit clinical trial results to ensure accuracy, consistency, and alignment with regulatory standards - Evaluate AI-generated clinical analyses for scientific soundness and regulatory relevance - Provide expert feedback that directly improves how AI models reason about clinical trial data, endpoints, and outcomes - Help establish the scientific credibility of AI outputs in clinical and biomedical contexts Who You Are - Senior-level professional with hands-on experience designing clinical trial protocols for regulatory submission - Deep expertise interpreting clinical data for agencies such as the FDA, EMA, or equivalent global bodies - Strong background in clinical research methodology, biostatistics, or translational science - Naturally rigorous — you hold AI-generated content to the same standards you'd apply in a real submission - Self-directed and comfortable delivering high-quality work independently Nice to Have - Prior experience with data annotation, data quality evaluation, or AI training workflows - Familiarity with AI tools or clinical NLP systems as an end user - Experience spanning multiple therapeutic areas or regulatory jurisdictions - Background in academic clinical research, CRO environments, or regulatory consulting Why Join Us - Work directly on frontier AI systems that are reshaping clinical and biomedical research - Fully remote and flexible — work when and where it suits you - Freelance autonomy with the structure of meaningful, expert-level work - Influence how AI understands, evaluates, and communicates real-world clinical evidence at scale - Potential for ongoing work and contract extension as new projects launch
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