Principal Clinical Scientist
About this role
About the Role What if your career-long expertise in clinical trial design and regulatory science could directly shape how AI understands and reasons about medical evidence? We're looking for a Principal Clinical Scientist to bring senior-level rigor to frontier AI research — ensuring the clinical data and analyses powering next-generation AI systems meet the same exacting standards expected in real-world regulatory submissions. This is a fully remote, flexible contract role built for experienced clinical scientists who want to contribute to something genuinely new. No AI background required — just deep command of clinical research and a sharp eye for scientific quality. - Organization: Alignerr - Type: Hourly Contract - Location: Remote - Commitment: 10–40 hours/week What You'll Do - Design and critically review clinical trial protocols used to generate high-quality, regulatory-grade datasets for AI training - Interpret and audit clinical trial results for accuracy, consistency, and alignment with regulatory expectations - Evaluate AI-generated clinical analyses for scientific soundness and methodological integrity - Provide structured expert feedback that directly improves how AI models reason about clinical evidence, outcomes, and trial data - Work independently and asynchronously — fully on your own schedule Who You Are - Senior-level experience designing clinical trial protocols intended for regulatory submission - Deep expertise interpreting clinical data for agencies such as the FDA, EMA, or equivalent global bodies - Strong grounding in clinical research methodology, biostatistics, or translational science - Naturally detail-oriented with a rigorous, systematic approach to evaluating scientific quality - Clear and precise written communicator — able to document findings and feedback with authority - No prior AI or tech experience required Nice to Have - Prior involvement in data annotation, data quality assurance, or evaluation systems - Experience reviewing or contributing to clinical evidence packages for drug, device, or diagnostic submissions - Background spanning multiple therapeutic areas or trial phases - Familiarity with AI-generated content or model evaluation workflows Why Join Us - Work directly on frontier AI systems with real impact on clinical and biomedical research - Fully remote and flexible — work when and where it suits you - Freelance autonomy with the structure of meaningful, expert-level work - Influence how AI understands, evaluates, and communicates real-world clinical evidence - Potential for ongoing work and contract extension as new projects launch
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