Principal Clinical Scientist
About this role
About the Role What if your career designing rigorous clinical trials and interpreting regulatory-grade data could directly influence how AI understands medicine? We're looking for a Principal Clinical Scientist to bring senior-level clinical expertise into the development of cutting-edge AI systems — helping ensure these models reason about clinical evidence the way a seasoned scientist would. This is a fully remote, flexible contract role built for experienced clinical researchers who want to work at the intersection of science and frontier AI. No AI background required — just deep clinical expertise and a sharp eye for scientific rigor. - Organization: Alignerr - Type: Hourly Contract - Location: Remote - Commitment: 10–40 hours/week What You'll Do - Design and review clinical trial protocols used to generate high-quality, regulator-ready datasets for AI training and evaluation - Interpret and audit clinical trial results to ensure accuracy, consistency, and alignment with regulatory standards - Evaluate AI-generated clinical analyses for scientific soundness and compliance with FDA, EMA, or equivalent agency expectations - Provide expert feedback that directly shapes how AI models understand, reason about, and evaluate clinical trial data and outcomes - Flag gaps in methodology, data quality, or regulatory relevance across AI-generated clinical content Who You Are - Senior-level clinical researcher with hands-on experience designing trial protocols for regulatory submission - Deep expertise interpreting clinical data for agencies such as the FDA, EMA, or equivalent regulatory bodies - Strong grounding in clinical research methodology, biostatistics, or translational science - Naturally rigorous — you hold AI-generated outputs to the same standard you'd apply in a real submission - Self-directed and comfortable working independently in an asynchronous environment Nice to Have - Prior experience with data annotation, data quality evaluation, or AI output assessment - Background in pharmacology, oncology, rare disease, or another specialized therapeutic area - Familiarity with ICH guidelines, GCP standards, or regulatory submission frameworks - Experience working across multidisciplinary research teams Why Join Us - Work directly on frontier AI systems that are reshaping how clinical and biomedical research is conducted - Influence how AI understands and evaluates real-world clinical evidence — at a scale no individual trial could achieve - Fully remote and flexible — work when and where it suits you - Freelance autonomy with the structure of meaningful, high-impact, task-based work - Collaborate with world-leading AI research labs on problems that matter - Potential for ongoing work and contract extension as new projects launch
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