Principal Clinical Scientist
About this role
About the Role What if your career-long expertise in clinical trial design and regulatory science could directly shape how AI understands and evaluates medical evidence? We're looking for a Principal Clinical Scientist to bring senior-level clinical rigor to the AI systems that are redefining biomedical research. At Alignerr, we partner with the world's leading AI research labs to build and train cutting-edge models. In this role, you won't just consult on the margins — you'll be at the center of ensuring that AI systems reason about clinical data the way the world's most demanding regulators expect. This is a fully remote, flexible contract role designed for senior clinical professionals who want to work at the frontier of AI without leaving their scientific roots behind. - Organization: Alignerr - Type: Hourly Contract - Location: Remote - Commitment: 10–40 hours/week What You'll Do - Design and review clinical trial protocols used to generate high-quality, regulator-ready training datasets for AI systems - Interpret and audit clinical trial results to ensure accuracy, consistency, and alignment with regulatory standards - Evaluate AI-generated clinical analyses for scientific soundness and regulatory relevance - Provide expert, structured feedback that improves how AI models reason about clinical trial data, endpoints, and outcomes - Serve as a domain authority at the intersection of clinical science and frontier AI development Who You Are - Senior-level clinical scientist with hands-on experience designing trial protocols for regulatory submission - Deep expertise interpreting clinical data for agencies such as the FDA, EMA, or equivalent bodies - Strong grounding in clinical research methodology, biostatistics, or translational science - Rigorous, detail-oriented thinker who can clearly articulate why something meets — or falls short of — regulatory expectations - Self-directed and comfortable working independently in an asynchronous, remote environment Nice to Have - Prior experience with data annotation, data quality review, or AI evaluation workflows - Background in clinical data management or medical writing for regulatory submissions - Familiarity with AI tools or interest in how machine learning is applied in biomedical contexts Why Join Us - Work directly on frontier AI systems making a real impact on clinical and biomedical research - Fully remote and flexible — structure your hours around your life, not the other way around - Freelance autonomy with the intellectual depth of genuinely meaningful, senior-level work - Influence how AI understands, evaluates, and communicates real-world clinical evidence at scale - Collaborate with world-class AI researchers and clinical domain experts across the globe - Potential for ongoing work and contract extension as new projects launch
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