Principal Clinical Scientist
About this role
About the Role What if your years of clinical trial expertise could directly influence how AI understands and reasons about medical evidence — at a scale that impacts millions of patients worldwide? We're looking for a Principal Clinical Scientist to bring senior-level rigor to AI-driven research workflows. You'll work alongside world-leading AI research teams to ensure that clinical data used to train and evaluate advanced AI systems meets the scientific and regulatory standards expected in real-world submissions. This is a fully remote, flexible contract role built for experienced clinical scientists who want to do meaningful work on their own terms. - Organization: Alignerr - Type: Hourly Contract - Location: Remote - Commitment: 10–40 hours/week What You'll Do - Design and review clinical trial protocols used to generate high-quality, regulator-ready datasets for AI training - Interpret and audit clinical trial results to ensure accuracy, consistency, and regulatory relevance - Evaluate AI-generated clinical analyses for scientific soundness and alignment with FDA, EMA, or equivalent regulatory expectations - Provide expert, structured feedback to improve how AI models reason about clinical trial data and real-world outcomes - Help define the standards by which AI systems engage with clinical evidence — shaping the field from the ground up Who You Are - Senior clinical scientist with hands-on experience designing trial protocols for regulatory submission - Deep expertise interpreting clinical data for major regulatory agencies (FDA, EMA, or equivalent) - Strong foundation in clinical research methodology, biostatistics, or translational science - Rigorous, detail-oriented thinker who holds AI outputs to the same standards as a regulatory dossier - Self-directed and comfortable working independently in an async, remote environment Nice to Have - Prior experience with data annotation, data quality assurance, or evaluation systems - Background in pharmacovigilance, post-market surveillance, or real-world evidence - Familiarity with AI tools or clinical data platforms - Experience in translational research or early-phase drug development Why Join Us - Work directly on frontier AI systems with real impact on clinical and biomedical research - Fully remote and async — work when and where it suits you, with no commute and no fixed schedule - Freelance autonomy: choose your hours, control your workload, and collaborate globally - Influence how AI understands, evaluates, and communicates real-world clinical evidence - Contribute to work that sits at the intersection of regulatory science and cutting-edge AI - Potential for ongoing collaboration and contract extension as new projects launch
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