Principal Clinical Scientist
About this role
About the Role What if your expertise in clinical trial design and regulatory science could directly shape how AI reasons about clinical evidence — influencing the systems that will power the next generation of biomedical research? We're looking for a Principal Clinical Scientist to bring senior-level rigor to AI-driven research workflows. You'll work alongside world-leading AI research teams to ensure that clinical data used to train and evaluate advanced AI systems meets the standards expected in real-world regulatory submissions. This is a fully remote, flexible contract role built for seasoned clinical scientists who want to do meaningful, frontier work — on their own schedule. - Organization: Alignerr - Type: Hourly Contract - Location: Remote - Commitment: 10–40 hours/week What You'll Do - Design and review clinical trial protocols used to generate high-quality, regulator-ready datasets for AI training - Interpret and audit clinical trial results to ensure accuracy, consistency, and regulatory relevance - Evaluate AI-generated clinical analyses for scientific soundness and alignment with FDA, EMA, or equivalent regulatory expectations - Provide structured expert feedback that directly improves how AI models reason about clinical trial data, endpoints, and outcomes - Help establish the scientific standards that define how frontier AI understands clinical evidence Who You Are - Senior-level clinical scientist with hands-on experience designing trial protocols for regulatory submission - Deep expertise interpreting clinical data for major regulatory agencies (FDA, EMA, or equivalent) - Strong grounding in clinical research methodology, biostatistics, translational science, or a related discipline - Meticulous, detail-oriented, and comfortable working independently with minimal oversight - Able to translate complex regulatory and clinical concepts into clear, structured written feedback Nice to Have - Prior experience with data annotation, data quality evaluation, or AI training workflows - Background in pharmacovigilance, health technology assessment, or evidence synthesis - Familiarity with AI tools or clinical decision support systems as an end user Why Join Us - Work directly on frontier AI systems making a real impact on clinical and biomedical research - Fully remote and flexible — work when and where it suits you - Freelance autonomy with the structure of meaningful, project-based work - Influence how AI understands, evaluates, and reasons about real-world clinical evidence - Collaborate with leading AI research teams and labs on cutting-edge projects - Potential for ongoing work and contract extension as new projects launch
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