Principal Clinical Scientist
About this role
About the Role What if your career-long expertise in clinical trial design and regulatory science could directly influence how AI reasons about medicine, data, and patient outcomes? We're looking for a Principal Clinical Scientist to bring senior-level rigor to one of the most consequential challenges in AI development: ensuring that AI systems trained on clinical data actually understand it the way regulators, researchers, and clinicians do. This is a fully remote, flexible contract role built for experienced clinical scientists who want to work at the frontier of AI and biomedical research — on their own terms. - Organization: Alignerr - Type: Hourly Contract - Location: Remote - Commitment: 10–40 hours/week What You'll Do - Design and critically review clinical trial protocols used to generate high-quality, regulator-ready datasets for AI training - Interpret and audit clinical trial results for accuracy, consistency, and alignment with regulatory standards - Evaluate AI-generated clinical analyses for scientific soundness and compliance with FDA, EMA, or equivalent agency expectations - Provide expert, structured feedback that directly improves how AI models reason about clinical evidence, trial methodology, and outcomes - Flag gaps, inconsistencies, or methodological errors in AI-generated clinical content - Work independently and asynchronously — fully on your own schedule Who You Are - Senior-level experience designing clinical trial protocols for regulatory submission — you've done this at a high level in the real world - Deep expertise interpreting clinical data for agencies such as the FDA, EMA, or equivalent regulatory bodies - Strong grounding in clinical research methodology, biostatistics, or translational science - Naturally rigorous and detail-oriented — you hold AI-generated content to the same standards you'd apply to a real submission - Clear and precise written communicator who can articulate complex scientific reasoning in structured feedback Nice to Have - Prior experience with data annotation, data quality assurance, or evaluation systems - Background in regulatory affairs, clinical operations, or medical writing - Familiarity with AI tools or scientific evaluation workflows - Experience working across therapeutic areas or with international regulatory submissions Why Join Us - Work directly on frontier AI systems that are reshaping clinical and biomedical research - Influence how AI understands, evaluates, and reasons about real-world clinical evidence — at scale - Fully remote and flexible — work when and where it suits you - Freelance autonomy with the structure of meaningful, high-impact work - Collaborate with world-leading AI research teams and labs - Potential for ongoing work and contract extension as new projects launch
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