Principal Clinical Scientist
About this role
About the Role What if your deep expertise in clinical trial design and regulatory science could directly influence how AI understands and evaluates real-world medical evidence? We're looking for a Principal Clinical Scientist to bring senior-level rigor to frontier AI research — helping ensure that the clinical intelligence built into next-generation AI systems meets the standards expected in real regulatory submissions. This is a fully remote, flexible contract role designed for experienced clinical scientists who want to do meaningful work at the intersection of medicine and AI — on their own schedule. - Organization: Alignerr - Type: Hourly Contract - Location: Remote - Commitment: 10–40 hours/week What You'll Do - Design and review clinical trial protocols used to generate high-quality, regulator-ready datasets for AI training and evaluation - Interpret and audit clinical trial results to ensure accuracy, consistency, and alignment with regulatory expectations - Evaluate AI-generated clinical analyses for scientific soundness and methodological rigor - Provide expert, structured feedback that directly improves how AI models reason about clinical trial data, endpoints, and outcomes - Work independently and asynchronously — fully on your own schedule Who You Are - Senior-level experience designing clinical trial protocols intended for regulatory submission - Deep expertise interpreting clinical data for agencies such as the FDA, EMA, or equivalent international bodies - Strong grounding in clinical research methodology, biostatistics, or translational science - Naturally detail-oriented with a systematic, evidence-driven approach to evaluation - Clear and precise written communicator — able to articulate complex scientific reasoning in structured feedback Nice to Have - Prior experience with data annotation, data quality assurance, or evaluation systems - Familiarity with AI tools or clinical informatics platforms - Background in pharmacology, oncology, rare disease, or another specialist therapeutic area - Experience contributing to regulatory dossiers, CTD submissions, or scientific advisory processes Why Join Us - Work directly on frontier AI systems impacting clinical and biomedical research at a global scale - Fully remote and flexible — work when and where it suits you - Freelance autonomy with the structure of meaningful, task-based expert work - Influence how AI understands, evaluates, and reasons about real-world clinical evidence - Collaborate with world-leading AI research teams and labs - Potential for ongoing work and contract extension as new projects launch
Application listings
Choose a source listing and check its country requirements.