Principal Clinical Scientist
About this role
About the Role What if your years of clinical trial expertise could directly shape how AI reasons about biomedical evidence — influencing systems that will impact research and patient outcomes for years to come? We're looking for a Principal Clinical Scientist to bring senior-level rigor into cutting-edge AI development. You'll work alongside world-leading AI research teams, ensuring that the clinical data and reasoning embedded in frontier AI models meets the standards you'd expect in a real-world regulatory submission. This is a fully remote, flexible contract role built for experienced clinical scientists who want to do meaningful work on their own terms. - Organization: Alignerr - Type: Hourly Contract - Location: Remote - Commitment: 10–40 hours/week What You'll Do - Design and review clinical trial protocols used to generate high-quality, regulator-ready training datasets - Interpret and audit clinical trial results to ensure accuracy, consistency, and regulatory relevance - Evaluate AI-generated clinical analyses for scientific soundness and alignment with regulatory expectations (FDA, EMA, or equivalent) - Provide expert, structured feedback that directly improves how AI models reason about clinical trial data and outcomes - Work independently and asynchronously — fully on your own schedule Who You Are - Senior-level experience designing clinical trial protocols intended for regulatory submission - Deep expertise interpreting clinical data for regulatory agencies such as the FDA, EMA, or equivalent bodies - Strong command of clinical research methodology, biostatistics, or translational science - Naturally rigorous and detail-oriented — you hold your work to the same standards regulators do - Clear, structured communicator who can articulate complex scientific reasoning in writing Nice to Have - Prior experience with data annotation, data quality review, or evaluation systems - Background in AI-adjacent roles such as digital health, clinical decision support, or health informatics - Familiarity with how AI systems are trained and evaluated Why Join Us - Work directly on frontier AI systems shaping the future of clinical and biomedical research - Influence how AI understands, evaluates, and reasons about real-world clinical evidence - Fully remote and flexible — work when and where it suits you - Freelance autonomy with the structure of meaningful, high-impact work - Collaborate with leading AI research teams and labs globally - Potential for ongoing work and contract extension as new projects launch
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