Principal Clinical Scientist
About this role
About the Role What if your career-long expertise in clinical trial design and regulatory science could directly shape how the world's most advanced AI systems understand biomedical evidence? We're looking for a Principal Clinical Scientist to bring senior-level rigor to AI-driven research workflows. Your work will help ensure that AI models reason about clinical data the way the best scientists do — accurately, methodically, and in line with the standards expected by the FDA, EMA, and equivalent agencies worldwide. This is a fully remote, flexible contract role built for experienced clinical scientists who want to contribute to something genuinely new — without leaving behind the expertise it took years to build. - Organization: Alignerr - Type: Hourly Contract - Location: Remote - Commitment: 10–40 hours/week What You'll Do - Design and review clinical trial protocols used to generate high-quality, regulator-ready datasets for AI training and evaluation - Interpret and audit clinical trial results, ensuring accuracy, consistency, and regulatory relevance - Evaluate AI-generated clinical analyses for scientific soundness and alignment with regulatory expectations - Identify gaps, errors, and weaknesses in how AI models reason about clinical outcomes and trial methodology - Provide structured expert feedback that directly improves how frontier AI systems understand real-world clinical evidence - Work independently and asynchronously — fully on your own schedule Who You Are - Senior-level clinical scientist with hands-on experience designing and reviewing clinical trial protocols for regulatory submission - Deep expertise interpreting clinical data for agencies such as the FDA, EMA, or equivalent - Strong command of clinical research methodology, biostatistics, or translational science - Able to critically evaluate complex scientific outputs and communicate findings with precision - Detail-oriented and systematic — you hold work to a high standard Nice to Have - Prior experience with data annotation, data quality review, or evaluation systems - Familiarity with AI tools or machine learning workflows in a biomedical context - Background in pharmacology, epidemiology, or regulatory affairs Why Join Us - Work directly on frontier AI systems that are reshaping clinical and biomedical research - Influence how AI understands, evaluates, and communicates real-world clinical evidence at scale - Fully remote and flexible — work when and where it suits you - Freelance autonomy with the structure of meaningful, high-impact work - Collaborate with leading AI research teams and labs on cutting-edge projects - Potential for ongoing work and contract extension as new projects launch
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