Principal Clinical Scientist
About this role
About the Role What if your career-long expertise in clinical trial design and regulatory science could directly influence how AI understands and reasons about clinical evidence? We're looking for a Principal Clinical Scientist to bring senior-level rigor to AI-driven research — ensuring the clinical data powering next-generation AI systems meets the standards expected in real-world regulatory submissions. This is a fully remote, flexible contract role designed for experienced clinical scientists who want to work at the frontier of AI and biomedical research. No AI background required — just deep clinical expertise and a sharp eye for scientific quality. - Organization: Alignerr - Type: Hourly Contract - Location: Remote - Commitment: 10–40 hours/week What You'll Do - Design and review clinical trial protocols used to generate high-quality, regulatory-grade datasets for AI training and evaluation - Interpret and audit clinical trial results to ensure accuracy, consistency, and alignment with regulatory standards - Evaluate AI-generated clinical analyses for scientific soundness and regulatory relevance - Provide expert, structured feedback that helps AI models reason more accurately about clinical trial data, outcomes, and methodology - Work independently and asynchronously — fully on your own schedule Who You Are - Senior-level experience designing clinical trial protocols for regulatory submission (FDA, EMA, or equivalent) - Deep expertise interpreting clinical data within regulatory frameworks - Strong foundation in clinical research methodology, biostatistics, or translational science - Naturally detail-oriented with high standards for scientific accuracy and consistency - Clear and effective written communicator able to document feedback in structured formats Nice to Have - Prior experience with data annotation, data quality review, or AI evaluation workflows - Background in pharmacology, epidemiology, or outcomes research - Familiarity with AI tools or clinical decision-support systems - Experience working across multiple therapeutic areas or trial phases Why Join Us - Work directly on frontier AI systems shaping the future of clinical and biomedical research - Influence how AI understands, evaluates, and reasons about real-world clinical evidence - Fully remote and flexible — work when and where it suits you - Freelance autonomy with the structure of meaningful, expert-level work - Collaborate with leading AI research labs and teams pushing the boundaries of medical AI - Potential for ongoing work and contract extension as new projects launch
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