Principal Clinical Scientist
About this role
About the Role What if your career-long expertise in clinical trial design and regulatory science could directly shape how AI understands and reasons about clinical evidence? We're looking for a Principal Clinical Scientist to bring senior-level rigor to frontier AI research — ensuring the models influencing biomedical science are grounded in real-world regulatory standards. This is a fully remote, flexible contract role built for experienced clinical scientists who want to contribute to something genuinely new. No AI background required — just deep command of clinical trial methodology and regulatory data interpretation. - Organization: Alignerr - Type: Hourly Contract - Location: Remote - Commitment: 10–40 hours/week What You'll Do - Design and review clinical trial protocols used to generate high-quality, regulator-ready datasets for AI training - Interpret and audit clinical trial results for accuracy, consistency, and regulatory relevance - Evaluate AI-generated clinical analyses for scientific soundness and alignment with regulatory expectations (FDA, EMA, or equivalent) - Provide expert feedback that directly shapes how AI models reason about clinical trial data, outcomes, and methodology - Help define standards for how cutting-edge AI systems engage with biomedical and clinical research evidence Who You Are - Senior clinical scientist with hands-on experience designing protocols for regulatory submission - Deep expertise interpreting clinical data for regulatory agencies such as FDA, EMA, or equivalent bodies - Strong command of clinical research methodology, biostatistics, or translational science - Naturally rigorous — you hold your work to the standard that real submissions demand - Detail-oriented and able to clearly communicate complex scientific reasoning in writing - Comfortable working independently and asynchronously Nice to Have - Prior experience with data annotation, data quality review, or evaluation systems - Background in pharmacology, epidemiology, or health technology assessment - Familiarity with AI tools or data-driven research platforms Why Join Us - Work directly on frontier AI systems with real impact on clinical and biomedical research - Influence how AI understands, evaluates, and communicates real-world clinical evidence - Fully remote and flexible — work on your own schedule, from anywhere - Freelance autonomy with the substance of meaningful, expert-level work - Collaborate with world-leading AI research teams and labs - Potential for ongoing work and contract extension as new projects launch
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