Principal Clinical Scientist
About this role
About the Role What if your deep expertise in clinical trial design and regulatory science could directly shape how AI understands and evaluates real-world medical evidence? We're looking for a Principal Clinical Scientist to bring senior-level clinical rigor into cutting-edge AI research workflows — ensuring the AI systems influencing the future of medicine are built on scientifically sound, regulator-ready foundations. This is a fully remote, flexible contract role designed for experienced clinical scientists who want to do meaningful work at the frontier of biomedical AI — on their own terms. - Organization: Alignerr - Type: Hourly Contract - Location: Remote - Commitment: 10–40 hours/week What You'll Do - Design and review clinical trial protocols used to generate high-quality, regulatory-grade datasets for AI training and evaluation - Interpret and audit clinical trial results to ensure accuracy, consistency, and alignment with regulatory standards - Evaluate AI-generated clinical analyses for scientific soundness and adherence to regulatory expectations (FDA, EMA, or equivalent) - Provide structured expert feedback that directly improves how AI models reason about clinical trial data, endpoints, and outcomes - Help define the standard of scientific quality for clinical content used in frontier AI systems Who You Are - Senior clinical scientist with hands-on experience designing clinical trial protocols for regulatory submission - Deep familiarity with interpreting clinical data for regulatory agencies such as the FDA, EMA, or equivalent bodies - Strong grounding in clinical research methodology, biostatistics, or translational science - Meticulous and systematic — you hold clinical data to the highest standard of rigor - Comfortable working independently and delivering structured, high-quality written evaluations Nice to Have - Prior experience with data annotation, data quality assurance, or AI evaluation systems - Background in pharmacovigilance, clinical operations, or medical affairs - Familiarity with AI tools or how machine learning models are trained and assessed Why Join Us - Work directly on frontier AI systems that are reshaping clinical and biomedical research - Influence how the next generation of AI understands, evaluates, and reasons about real-world clinical evidence - Fully remote and flexible — work when and where it suits you - Freelance autonomy with the structure of meaningful, high-stakes scientific work - Collaborate with world-leading AI research teams and labs - Potential for ongoing work and contract extension as new projects launch
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