Principal Clinical Scientist
About this role
About the Role What if your years of clinical trial expertise could directly influence how AI reasons about medical evidence, regulatory submissions, and patient outcomes? We're looking for a Principal Clinical Scientist to bring senior-level rigor to AI-driven research — ensuring that the clinical knowledge embedded in next-generation AI systems meets the highest scientific and regulatory standards. This is a fully remote, flexible contract role designed for experienced clinical scientists who want to do meaningful work at the frontier of AI and biomedical research. - Organization: Alignerr - Type: Hourly Contract - Location: Remote - Commitment: 10–40 hours/week What You'll Do - Design and review clinical trial protocols used to generate high-quality, regulator-ready datasets for AI training - Interpret and audit clinical trial results to ensure accuracy, consistency, and regulatory relevance - Evaluate AI-generated clinical analyses for scientific soundness and alignment with FDA, EMA, or equivalent regulatory expectations - Provide expert feedback that directly improves how AI models reason about clinical trial data, endpoints, and outcomes - Help establish standards for how frontier AI systems understand and evaluate real-world clinical evidence Who You Are - Senior-level experience designing clinical trial protocols for regulatory submission - Deep expertise interpreting clinical data for regulatory agencies such as the FDA, EMA, or equivalent - Strong background in clinical research methodology, biostatistics, or translational science - Naturally detail-oriented with a rigorous, systematic approach to evaluating data quality - Able to communicate complex clinical concepts clearly in written feedback Nice to Have - Prior experience with data annotation, data quality assurance, or evaluation systems - Familiarity with AI tools or clinical informatics platforms - Background in pharmacovigilance, medical affairs, or health outcomes research - Experience working across multiple therapeutic areas or global regulatory frameworks Why Join Us - Work directly on frontier AI systems impacting clinical and biomedical research worldwide - Fully remote and flexible — work on your own schedule, from anywhere - Freelance autonomy with the structure of meaningful, expert-level work - Influence how AI understands, evaluates, and communicates real-world clinical evidence - Collaborate with leading AI research teams and labs on cutting-edge projects - Potential for ongoing work and contract extension as new projects launch
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