Principal Clinical Scientist
About this role
About the Role What if your expertise in clinical trial design and regulatory-grade data interpretation could directly shape how AI reasons about biomedical evidence — influencing systems used by researchers and clinicians worldwide? We're looking for a Principal Clinical Scientist to bring senior-level rigor to AI-driven research workflows. You'll work with cutting-edge AI teams to ensure clinical data used in training and evaluation meets the standards expected in real-world regulatory submissions. This is a fully remote, flexible contract role built for experienced clinical scientists who want to do meaningful work — on their own schedule. - Organization: Alignerr - Type: Hourly Contract - Location: Remote - Commitment: 10–40 hours/week What You'll Do - Design and review clinical trial protocols used to generate high-quality, regulator-ready datasets for AI training - Interpret and audit clinical trial results for accuracy, consistency, and regulatory relevance - Evaluate AI-generated clinical analyses for scientific soundness and alignment with FDA, EMA, or equivalent regulatory expectations - Provide structured expert feedback that helps AI models reason more accurately about clinical trial data, outcomes, and evidence - Flag methodological gaps, ambiguities, or misrepresentations in AI-generated clinical content Who You Are - Senior-level professional with deep experience designing clinical trial protocols for regulatory submission - Highly skilled at interpreting clinical data for regulatory agencies such as the FDA, EMA, or equivalent bodies - Strong grounding in clinical research methodology, biostatistics, or translational science - Detail-oriented and systematic — you hold clinical data to the highest standards of rigor - Comfortable working independently and asynchronously in a remote, task-based environment Nice to Have - Prior experience with data annotation, data quality evaluation, or AI content review - Familiarity with AI tools or language model outputs in a scientific context - Background in biomedical informatics, health technology assessment, or evidence synthesis Why Join Us - Work directly on frontier AI systems making an impact in clinical and biomedical research - Influence how AI understands, evaluates, and communicates real-world clinical evidence - Fully remote and flexible — work when and where it suits you - Freelance autonomy with the structure of meaningful, expert-level work - Collaborate with leading AI research teams and labs at the cutting edge of the field - Potential for ongoing work and contract extension as new projects launch
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