Principal Clinical Scientist
About this role
About the Role What if your years of clinical trial expertise could directly shape how AI reasons about biomedical evidence — influencing the systems that will power the next generation of clinical research? We're looking for a Principal Clinical Scientist to bring senior-level rigor to AI-driven research workflows. You'll work with cutting-edge AI systems developed alongside the world's leading research labs, ensuring that clinical data used to train and evaluate these models meets the exacting standards expected in real-world regulatory submissions. This is a fully remote, flexible contract role — built for senior clinical professionals who want meaningful, high-impact work on their own schedule. - Organization: Alignerr - Type: Hourly Contract - Location: Remote - Commitment: 10–40 hours/week What You'll Do - Design and review clinical trial protocols used to generate high-quality, regulator-ready datasets for AI training - Interpret and audit clinical trial results to ensure accuracy, consistency, and regulatory relevance - Evaluate AI-generated clinical analyses for scientific soundness and alignment with FDA, EMA, or equivalent agency expectations - Provide expert, structured feedback that directly improves how AI models reason about clinical trial data, endpoints, and outcomes - Help define the gold standard for how clinical evidence is represented and understood within advanced AI systems Who You Are - Senior-level experience designing clinical trial protocols intended for regulatory submission - Deep expertise interpreting clinical data for major regulatory agencies (FDA, EMA, or equivalent) - Strong grounding in clinical research methodology, biostatistics, or translational science - Meticulous, detail-oriented, and comfortable working independently in an asynchronous environment - Clear and precise written communicator — you can explain complex clinical reasoning in structured, actionable terms Nice to Have - Prior experience with data annotation, data quality review, or evaluation systems - Background in pharmacovigilance, medical writing, or clinical operations - Familiarity with AI tools or data evaluation workflows Why Join Us - Work directly on frontier AI systems making a real impact on clinical and biomedical research - Fully remote and flexible — work when and where it suits you - Freelance autonomy with the structure of meaningful, expert-level work - Influence how AI understands and evaluates real-world clinical evidence at a foundational level - Collaborate with a global network of domain experts and leading AI research teams - Potential for ongoing work and contract extension as new projects launch
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