Principal Clinical Scientist
About this role
About the Role What if your career spent designing rigorous clinical trials and interpreting regulatory-grade data could directly influence how AI reasons about medicine? We're looking for a Principal Clinical Scientist to bring senior-level clinical expertise into the development of cutting-edge AI systems — ensuring the models shaping the future of biomedical research are built on a foundation of scientific rigor. This is a fully remote, flexible contract role. You won't be running trials or filing submissions — you'll be doing something arguably more consequential: teaching AI to think like a seasoned clinical scientist. - Organization: Alignerr - Type: Hourly Contract - Location: Remote - Commitment: 10–40 hours/week What You'll Do - Design and review clinical trial protocols used to generate high-quality, regulator-ready training datasets for AI systems - Interpret and audit clinical trial results to ensure accuracy, consistency, and alignment with regulatory standards - Evaluate AI-generated clinical analyses for scientific soundness and regulatory relevance - Identify gaps, errors, and weaknesses in how AI models reason about clinical evidence — and provide expert feedback to correct them - Help define what "good" looks like when AI tackles clinical trial data, outcomes, and methodology - Work independently and asynchronously on task-based assignments — on your own schedule Who You Are - Senior clinical scientist with deep, hands-on experience designing clinical trial protocols for regulatory submission - Expert interpreter of clinical data for agencies such as the FDA, EMA, or equivalent regulatory bodies - Strong grounding in clinical research methodology, biostatistics, or translational science - Precise, rigorous thinker who can spot flawed reasoning or incomplete analysis quickly - Clear written communicator who can document feedback in structured, actionable formats - Self-motivated and reliable when working independently without direct supervision Nice to Have - Prior experience with data annotation, data quality evaluation, or AI training workflows - Background in regulatory affairs, pharmacovigilance, or clinical operations - Familiarity with AI tools or model evaluation platforms as an end user - Experience in oncology, rare disease, or other complex therapeutic areas Why Join Us - Work on frontier AI systems alongside leading AI research labs — at the cutting edge of clinical and biomedical AI - Fully remote and flexible — work when and where it suits you - Freelance autonomy with the structure of meaningful, expert-level work - Make a direct, lasting impact on how AI understands and evaluates real-world clinical evidence - Influence the standards that define how AI models approach regulatory science - Potential for ongoing work and contract extension as new projects launch
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